Guidance for Sustainable Futures
This includes 'Interpretative Assistance' documentation for the assessment of discrete organic chemicals.
EPI Suite™ estimates physical / chemical properties (melting point, water solubility, etc.) and environmental fate properties (breakdown in water or air, etc.) which can indicate where a chemical will go in the environment and how long it will stay there.
ECOSAR uses structure-activity relationships (SARs) to predict the aquatic toxicity of untested chemicals based on their structural similarity to chemicals for which aquatic studies are available. Application of structure activity relationships is a technique routinely used by the U.S. EPA Office of Pollution Prevention and Toxics under the New Chemicals Program to estimate the toxicity of chemicals being reviewed in response to Pre-Manufacture Notices mandated under Section 5 of the Toxic Substances Control Act (TSCA). The toxicity data used to build the SARs are collected from publicly available experimental studies and confidential submissions provided to the U.S. EPA New Chemicals Program. The SARs in ECOSAR express correlations between a compound's physicochemical properties and its toxicity within specific chemical classes.
The PBT Profiler is an online risk-screening tool that predicts a chemical's potential to persist in the environment, bio-concentrate in animals, and be toxic, properties which cause concern for human health and the environment. PBT stands for Persistence, Bioaccumulation and Toxicity.